Themis Bioscience’s Vaccine against Chikungunya Successful in Phase 1

An article from VaccineNation
November 20, 2014
The induction of neutralizing antibodies by a prophylactic Chikungunya vaccine candidate has now been confirmed by the final results of a phase 1 clinical trial, as well as its tolerability and safety. Detailed information of the trial has been presented at two international conferences. The vaccine candidate was developed under a R&D collaboration between Themis Bioscience GmbH and the Institut Pasteur (Paris, France) based upon a measles vaccine vector technology (Themaxyn®). Following this positive trial outcome both parties agreed to broaden the scope of their collaboration.
 
The Vienna-based biotech company Themis Bioscience GmbH (‘Themis’) has received final results of a phase 1 clinical study of its prophylactic Chikungunya fever vaccine. The study was carried out on 42 subjects at the Department of Clinical Pharmacology of the Vienna General Hospital (Allgemeines Krankenhaus der Stadt Wien) and confirms the previous interim results: The candidate not only proved to be well tolerated and safe, but also exhibited the required immune response in the form of neutralizing antibodies in all vaccinated subjects. Remarkably, the immune response was clearly dose-dependent with even the lowest dose being effective. 
 
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