Vienna's Hookipa Biotech starts first-in-human CMV vaccine trial

An article by FiercePharma
July 26, 2016

One month after luring influential biotech entrepreneur Jörn Aldag to serve as its CEO, Vienna, Austria’s Hookipa Biotech is taking a cytomegalovirus vaccine candidate into a first-in-human trial. Dubbed HB-101, the vaccine will undergo Phase I testing in 54 individuals, producing interim data late this year and early next year.

The vaccine is based on Hookipa’s Vaxwave platform, which the startup says can boost the immune system through repeated applications by stimulating B-cell and CD8+ T-cell responses. The vaccine--a bivalent candidate with two rLCMV vectors--has shown promise in preclinical studies, Aldag said in a statement.

The 15-month trial will test the vaccine at low, middle and high doses, as well as against placebo; the primary endpoint is safety.

Vaccine development against cytomegalovirus, which is common throughout the world but serious for immunocompromised patients and infants, has been named at the “highest priority by the US Institute of Medicine,” Aldag said in a statement. A successful vaccine could reduce morbidity, mortality and costs associated with the virus.

 

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